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Neuraleaf Dosing Guide

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Neuraleaf dosing guide

People use CBD for a variety of reasons, including for health-related purposes. Dosages of CBD differ between people and conditions, depending on a range of factors such as individual metabolism, body mass, sensitivity, target tissue and intended effect. As such, there are no set doses, rather a dosing method that is unique to each individual based on their needs. Dose scaling methodology, choice and/or combination of products used do vary between different conditions and unique needs.

For joint/muscle/skin problems: 

Commonly reported joint/muscle complaints to include swelling, pain and stiffness. 

Commonly reported skin issues to include inflammation (such as eczema, psoriasis or acne) and pain (HS). 

The topical Nano CBD salve should be rubbed into the affected area 3-4 times per day. If the issue is isolated to 1-2 body parts, using the balm may be enough to relieve symptoms. If 3 or more body parts are affected, using in combination with a slow-releasing oral formulation such as the Micellar Capsules or Entourage Oil is recommended. 3+ body parts indicate a systemic rather than local issue, so combining the application of Nano Salve on the affected areas while taking slow release CBD twice per day (starting at a low dose and tapering up gradually, see guidance below). Combination of a slow-release oral with a topical allows the CBD to build up a constant blood level, allowing the blood to deliver the CBD to affected areas from the inside, while application of the topical allows penetration from the outside.

For Psych problems: 

Mental wellbeing is extremely important. Many people in the modern world suffer from worry and sadness, and when this becomes too great, it manifests as anxiety or depression. Sometimes too much mental stress can even trigger a psychotic incident. Some people use CBD to treat these symptoms. 

Most commonly, symptoms associated with worsening forms of sadness, worry and paranoia are felt constantly but can worsen and become severe episodically. For this reason, it is recommended to combine a slow-release CBD formulation (such as Micellar Capsules or Entourage Oil) with the only rapid-release CBD product available on the market- Ultra Nano 4X. This is a strong product that uses proprietary technology for rapid absorption and widespread cellular uptake, providing relief that is often felt within minutes, if not seconds by some. The slow-release allows the severity of the constant symptoms to reduce and also reduces the frequency of worse episodes. The rapid relief Ultra Nano 4X can be used to relieve symptoms during episodes. This can be particularly helpful as, during these episodes, patients may not think clearly and make irrational decisions such as self-harming, due to a feeling which is intensely uncomfortable but would only last a short amount of time. Reducing the time and intensity of the stress during the episode reduces the risk of harm.

For Neurological and Pain problems: 

The nervous system contains the among the highest concentrations of cannabinoid receptors, along with the immune system, which is responsible for inflammation throughout the body. Pain conforms to 3 main types: Musculoskeletal (MSK), Neuropathic (nerve-related) and Inflammatory. Pharmaceutical drugs exist which can be effective for most people who experience MSK and inflammatory pain; patients who choose CBD to do so because the pharmaceutical alternatives do not provide sufficient relief, cause too many unwanted side effects, or both. Furthermore, MSK and Inflammatory pain often have a source, which may be responsive to targeted treatment, however again, many treatments carry variable levels of risk. 

Neuropathic pain, however, is neither easy to treat, nor has any clear source or cause. Our nervous system conducts all nerve signals, including those of pain. MSK and inflammatory pain signals are conducted by the nerves, arising from the source and being registered and felt in the brain. In this case, the nerves are not the issue and are working as they should, as injury should induce pain signals. However, in neuropathic pain, the nerves conjure up pain signals themselves. The nerves trick the brain into thinking and feeling an injury, despite none being present. Common characteristics of neuropathic pain include: burning, tingling, shooting pain and numbness. Few medicines are available to be prescribed for this, and patients commonly complain that they both do not work and cause side effects many find unbearable, preferring to feel the pain than deal with the drug’s side effects. This group of people often suffer without any option for treatment. For most individuals within this group, higher doses of CBD may be required before tangible relief can be felt.

Other Neurological symptoms include: numbness, tingling, tremor, spasms and seizures (among others), and may also benefit from the relief of excess nerve firing, termed ‘Neural Relief). 

For constant pain/symptoms, the use of a slow-release formulation such as the oil or capsules is suggested, using at the standard suggested dose. For neuropathic pain, start at the same dose but it is more appropriate to increase the dose, even beyond the maximum recommended dose (under the care of Neuraleaf’s Dr Adia, included free of charge). 

When pain is focussed within 1-3 regions, especially if there is an inflammatory element, the Nano Salve (balm) can be used up to 4 times a day on top of any oral use. 

Finally, for particularly severe neuropathic pain or neurological symptoms, the use of Ultra Nano 4X up to maximum dose used on top of the maximum dose of slow-release formulations is possible, with advice from Neuraleaf. This is because neuropathic pain is harder to treat and often requires more than equivalent other types of pain. 

Finally, for pain that is episodic or comes in waves, often in unpredictable patterns, the Nano 4X can be used PRN (or as needed), only when these worse episodes take place. This can be used for any type of pain, however, we only recommend combining max doses of slow-release (oil/capsules), Ultra Nano 4X (rapid relief liquid) and even the Nano Salve (balm) at max doses for Neurological/neuropathic disorders, after consultation with Dr Adia. 

Example Regimens: 

Back Pain – Back pain that is constant and prevents sleep:

Generalised Anxiety with Panic attack episodes: 


Period Pains: 


Please note: These are example regimens. Exact dosing, product choice, frequency and tapering vary between individuals for a number of reasons. This is why it is always suggested to take advantage of the free medical advice provided by Dr Adia at Neuraleaf!

Please note: This advice does not contain specific advice about exact doses in mg or ml. This is due to the fact that this varies between individuals and conditions. Dosing for Neuraleaf CBD products is done on a tapering up basis, until the intended effect, tolerability or max dose is reached. Max dose can be surpassed however this should be discussed with a Neuraleaf doctor before. There is exact dosage information on the PiL (Product Information Leaflets) provided with each order – however, is also provided below: 

Product Dosing

Entourage Oil (Slow Release) – 

Cheapest and lowest strength formulation. 

The lid is childproof. Push down on the lid of the bottle and twist anti-clockwise and break the seal.
The dropper is connected to the lid.

Take between 5 Drops (0.25ml – 25mg CBD, 30mg Total Spectrum) and 10 drops (0.5ml- 50mg CBD, 60mg Total Spectrum) up to twice a day. 

Drop the desired number of drops under the tongue and hold for 30-60 seconds before swallowing the remainder.
Please contact Neuraleaf Doctor before increasing the dose further. 

Micellar Capsules (Slow Release) – 

Best slow-release formulation, high strength with enhanced bioavailability. 

Shake the jar to separate the capsules.
Take 1-2 (50-100mg) capsules up to twice a day. Swallow with water.
Consult NeuraLeaf Doctor before increasing dose further. 

Ultra Nano 4X (Rapid Relief Liquid) 

Unique and proprietary to only Neuraleaf, Ultra Nano 4X is extremely strong with rapid relief. 

The lid is childproof. Push down on the lid of the bottle and twist anti-clockwise and break the seal.
There is a grey plastic adaptor on the opening of the bottle, and a purple syringe included within the box.

Place the tip of the syringe into the adaptor and draw 2.5ml – 5ml (40-80mg* Bioequivalent) 

Take up to twice a day, once in the day and once before bed. 

Consult NeuraLeaf Doctor before increasing dose further.

Nano Salve (Balm)

Wash hands with soap. Clean area before application. 

Rub on painful/inflamed joints/muscles and where there is skin inflammation such as eczema/acne/psoriasis, up to 4 times per day. 

Take a small amount of salve and rub it into the intended area. Only a small amount is needed as it spreads thinly and has a high CBD concentration. 

Can you buy CBD Oil online legally?

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can you buy cbd oil online legally

Yes, you can buy CBD Oil legally online. In fact, many cannabis-based products are available to buy online. However, you should only buy CBD products that have lab tests reports available.

CBD products must meet certain standards in order to be legally bought and sold in the UK. 

CBD is legal in the UK, however, the CBD oil UK law states that the product has to meet certain criteria to be lawfully available for human consumption. Read about the CBD oil UK law.

Many CBD products on the high street and online aren’t always properly authorised. So, when you’re looking to buy CBD oil, spray or capsules it’s best to buy them from trusted websites, pharmacies or stores to make sure these products are safe for consumption.

To be legal in the UK CBD products must have very low levels of THC so that they’re not psychoactive and won’t get you high.

If in doubt speak to your doctor or a pharmacist, and make sure to always read the label before taking CBD products.

View our catalogue of CBD products here.

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CBD Vs. THC. What’s the difference?

What is the Endocannabinoid System?

CBD vs. THC: What’s the Difference?

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cbd vs. thcAs the legal use of hemp and other cannabis products grows, consumers are becoming more curious about their options. This includes cannabidiol (CBD) and tetrahydrocannabinol (THC), two natural compounds found in plants of the Cannabis genus.

CBD can be extracted from hemp or cannabis?

Hemp and cannabis come from the Cannabis sativa plant. Legal hemp must contain 0.3 percent THC or less. CBD is sold in the form of gels, gummies, oils, supplements, extracts, and more.

THC is the main psychoactive compound in cannabis that produces a high sensation. It can be consumed by smoking cannabis. It’s also available in oils, edibles, tinctures, capsules, and more.

Both compounds interact with your body’s endocannabinoid system, but they have very different effects.

Read on to learn more about these compounds. While they may have a lot in common, they have some key differences that determine how they’re used.

CBD vs. THC: Chemical structure

Both CBD and THC have the exact same molecular structure: 21 carbon atoms, 30 hydrogen atoms, and 2 oxygen atoms. A slight difference in how the atoms are arranged accounts for the differing effects on your body.

Both CBD and THC are chemically similar to your body’s endocannabinoids. This allows them to interact with your cannabinoid receptors.

The interaction affects the release of neurotransmitters in your brain. Neurotransmitters are chemicals responsible for relaying messages between cells and have roles in pain, immune function, stress, and sleep, to name a few.

CBD vs. THC: Psychoactive components

Despite their similar chemical structures, CBD and THC don’t have the same psychoactive effects. CBD is psychoactive, just not in the same manner as THC. It doesn’t produce the high associated with THC. CBD is shown to help with anxiety, depression, and seizures.

THC binds with the cannabinoid 1 (CB1) receptors in the brain. It produces a high or sense of euphoria.

CBD binds very weakly, if at all, to CB1 receptors. CBD needs THC to bind to the CB1 receptor and, in turn, can help reduce some of the unwanted psychoactive effects of THC, such as euphoria or sedation.

CBD vs. THC: Legality

Across the world, cannabis-related laws are evolving regularly. 

Before you try to buy products with CBD or THC, it’s important to research your country’s laws.

If you possess cannabis-related products in a country where they’re illegal or don’t have a medical prescription in countries where the products are legal for medical treatment, you could face legal penalties.

CBD vs. THC: Drug testing

Cannabinoids like THC and CBD are stored in the body’s fat. They can show up on drug tests for several days or weeks after you use them.

Not every drug test will be able to detect CBD, but CBD-sensitive tests are available. Most standard drug tests will look for chemicals related to THC, so THC or marijuana use might show up on screening.

Likewise, hemp can produce some THC in addition to CBD, so a test could be positive for THC even if you haven’t used it.

It’s important to note that products that claim to be THC-free may not be free of THC, so if you’re drug tested, you shouldn’t use any CBD or THC products.

Why do people talk about THC content in CBD oil if THC and CBD are two different compounds?

CBD and THC are two of the most prominent cannabinoids found in the cannabis plant. Both cannabis and hemp produce CBD and THC.

However, cannabis has a higher concentration of THC. Hemp has a higher concentration of CBD.

The average cannabis strain today contains about 12 percent THC. CBD oil may contain small amounts of THC because it’s present at low levels in the hemp plant. CBD can have no more than 0.3 percent THC to be legal.

Read: CBD Not a Narcotic Drug
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What is the Endocannabinoid System?

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The Endocannabinoid System

Image source: Starkel Nutrition

The endocannabinoid system (ECS) is a complex cell-signalling system identified in the early 1990s by researchers exploring THC, a well-known cannabinoid. Cannabinoids are compounds found in cannabis.

How does the ECS work?

The ECS involves three core components: endocannabinoids, receptors, and enzymes.


Endocannabinoids, also called endogenous cannabinoids, are molecules made by your body. They’re similar to cannabinoids, but they’re produced by your body.

Experts have identified two key endocannabinoids so far:

These help keep internal functions running smoothly. Your body produces them as needed, making it difficult to know what typical levels are for each.

Endocannabinoid receptors

These receptors are found throughout your body. Endocannabinoids bind to them in order to signal that the ECS needs to take action.

There are two main endocannabinoid receptors:

Endocannabinoids can bind to either receptor. The effects that result depend on where the receptor is located and which endocannabinoid it binds to.

For example, endocannabinoids might target CB1 receptors in a spinal nerve to relieve pain. Others might bind to a CB2 receptor in your immune cells to signal that your body’s experiencing inflammation, a common sign of autoimmune disorders.


Enzymes are responsible for breaking down endocannabinoids once they’ve carried out their function.

There are two main enzymes responsible for this:

What are its functions?

The ECS is complicated, and experts haven’t yet determined exactly how it works or all of its potential functions.

 However, the following has been linked to the ECS:

These functions all contribute to homeostasis, which refers to the stability of your internal environment. For example, if an outside force, such as pain from an injury or a fever, throws off your body’s homeostasis, your ECS kicks in to help your body return to its ideal operation.

Today, experts believe that maintaining homeostasis is the primary role of the ECS.

Does the body naturally produce endocannabinoids?

Once scientists discovered cannabinoid receptors in the body, investigations began to determine whether humans produced endocannabinoids.

This led to the discovery of several chemicals similar to THC, such as AEA. AEA activates both CB1 and CB2.

Now, we know around seven of these chemicals exist within the body. As noted, the endocannabinoid system plays an important role in homeostasis and is involved in almost every biological function. In fact, the dysregulation of the ECS underpins some illnesses and pathologies.

How does CBD interact with the human body?

CBD does not interact with the endocannabinoid system in the same manner as THC.

Firstly, it does not activate either the CB1 or CB2 receptors. One of the characteristics that make CBD so unique is that it interacts with different protein receptors and enzymes in the body.

This causes its polypharmacological effects, as demonstrated by the licensed CBD medicine which treats epilepsy. As research develops, CBD is being used to relieve a wide array of symptoms and conditions.

This clinical research will build on the back of extremely strong anecdotal evidence from thousands of patients who have reported improvements in a wide array of afflictions.

As research progresses, dysregulation of the endocannabinoid system (ECS) is found to be implicated in many conditions, often due to low levels of endogenous cannabinoids.

CBD, activating the same receptors as endocannabinoids, replenishes cannabinoid levels and returns homeostatic balance to the ECS, alleviating whatever issue was manifesting as a result of this ECS imbalance. 

Read: CBD Not a Narcotic Drug
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How to Recycle CBD Bottles

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If you use CBD oil regularly, you may find yourself with a growing collection of empty tincture to recycle cbd bottle

The purpose of this article is to discuss how to recycle your empty CBD tincture bottles.

Can CBD Oil Bottles Be Recycled?

Yes, in most cases your glass tincture bottles can be recycled. You can check your local recycling program guidelines to confirm that glass bottles can be placed in your regular recycling bin. If not, your area may still offer curbside pickup or drop-off locations to recycle glass.

You can find out more here:

If you’re going to recycle the bottle, it should ideally be clean but it doesn’t have to be spotless. Rinsing the bottle out with warm water should suffice.

You should also remove the dropper top and either dispose of it or reuse it separately. For example, some users keep an extra dropper on hand if they are sharing their CBD with another person, or just in case they lose the dropper.

New to CBD?

We’re happy to help anyone new to CBD to give them the best advice possible. We are the only CBD retailer run and supported by experts.

If you would like advice on which CBD product to use, please don’t hesitate to get in touch with our team of experts.

Are you a professional in a high-stress job?

Read here how CBD can help professionals in high-stress jobs.

CBD for Professionals in High Stress Jobs

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You’re a professional, working in a fast paced environment, either from home or in a big office in a big city. You’re ambitious, you’re moving forward in your career, and you want to continue advancing your career and salary.

But with promotion comes greater responsibility, and with greater responsibility comes greater stress. Stress can impact your quality of life and in turn, the quality of your work. Stress can manifest in different ways, impacting your quality of sleep, intellectual capacity, attention, focus, stream of thought and energy levels. These will all lead to a decrease in productivity and efficiency at work and outside of work. Your capacity for social interaction is reduced, leading you to miss valuable networking opportunities. Your emotional intelligence is decreased, leading you to miss out on subconscious cues that can be vital to closing a deal or winning new clients.

It can lead to worse physical health outcomes by increasing the level of general inflammation in the body, increasing risk of autoimmune disease, and weaken the immune system, increasing risk of infections. This can require extended periods of sick leave, which can again harm your career progression.

Stress is also a leading cause of anxiety, depression and can even trigger more significant issues such as bipolar disorder or schizophrenia, especially if there is a family history. The consequences of these disorders cannot be emphasised enough and can lead to the destruction of relationships, inability to work, panic attacks, inability to sleep or inability to wake up, inability to eat, and possibly even psychosis where you may be a danger to yourself or others, and require being sectioned within a secure psychiatric facility.

This may seem like scaremongering, but it is proven by science and by statistics. Record numbers of talented and hard-working professionals are experiencing levels of stress that exceed acceptable levels by some margin, resulting in burnout. The lucky ones will realise this, and take a sabbatical or resign their job in order to repair their mental health, but not everyone has this level of self-awareness. Many will continue to fight through until they are let go from work due to poor results, or suffer a mental breakdown and severe mental health issues thereafter.

We can all agree that while the former is the superior option, neither is ideal. Ideally, you don’t want to take a break from your career at all. Doctors tend to provide really specific advice: Reduce responsibility and workload at work, sleep more, eat better, meditate (mindfulness) and exercise. This is really good advice, but it’s easier said than done. Almost all of those options require a finite resource: time. And as a busy professional, you barely have time to sleep 6 hours, go to work, complete projects at home, eat and exercise if you’re lucky. Most of the time- it’s not possible to do all of them, you must choose. And most of the time, it’s sleep and exercise that suffer, the two most vital. The solution – more time, but there are only 24 hours in the day. Previously, there was no healthy solution.

Drugs work, cocaine and Ritalin to focus and stay awake, Xanax and Valium to wind down and kill anxiety. But the disadvantages far outweigh the potential advantages – that was until now.

A new option for reducing anxiety, improving sleep and quality of life is CBD.

How can CBD help a busy professional?
Professionals working in stressful jobs have reported great results when using CBD for the following:

Why aren’t doctors prescribing or recommending CBD? Because the CBD available on the market is of such a poor quality (inaccurate minimal doses, toxins, heavy metals, Class B drug levels), and as such, no doctor would ever recommend such a dangerous product – until now.

Neuraleaf is the ONLY brand recommended by doctors in the UK, and was founded by a British doctor, who suffered from invasive nerve tumours resulting in significant chronic pain, and subsequent mental health issues. He was prescribed a number of pharmaceutical drugs. In the end, most of the burden of his condition was attributed to the side effects of these drugs. With CBD, he was able to come off the drugs and function as a normal healthy human being.

Who uses CBD? Neuraleaf CBD is the only pharmaceutical-grade CBD on the market, and as such, we are recommended by doctors and used by individuals who 1. Are well informed and care what goes into their body and 2. Choose high-quality products over cheaper alternatives. These tend to be busy professionals, and here is some of the feedback we’ve had.

James, Junior Associate, Goldman Sachs.
The main reason I got CBD was for sleep. I had tried CBD before and it didn’t work, until my psychiatrist recommended Neuraleaf as an alternative to sleeping pills.
I can’t get enough sleep, I’m working till after midnight most nights, and I have to be up for 6am. I average about 3-4 hours of sleep per night, and I can just about function. But after a few days of sleeping like this, I am far less productive.
After taking the CBD capsule before bed, I sleep for 3-4 hours but I wake up feeling like I’ve had 6 hours. This is by no means ideal, as my optimum sleep level is 7-8 hours. But it makes all the difference at work, and allows me to maintain close to 100% productivity until the weekend when I can catch up. I’ve recommended this to a few analysts who were struggling, and those who have used have benefitted.

Prakash, Assistant Manager, Financial Advisory, Deloitte
Every time I am set a deadline, the anxiety I feel leads me to prepare and plan ahead to ensure it gets done on time, in this sense, anxiety is not such a bad thing. But when deadlines are changed, when timelines are brought forwards, when a client needs a piece of working changing fully for the next morning, my anxiety gets so bad that its renders me almost useless. I panic, my brain stops working as my thoughts race, and I am unable to produce quality work. I don’t need CBD all the time, but when something unexpected happens, I take 5ml of Ultra Nano liquid, and within 2 minutes I feel calm and able to adjust my thoughts to tackle the new problem. I find it remarkable just how quickly it gets to work.

Anonymous, Senior Consultant, BCG
I’ve been working in consulting for almost 5 years now, and it’s taken a toll on my mental health. I’ve been on antidepressants for 2 years now and the doses gradually increase as my career has advanced and my stress levels increase. I’m not sure if the antidepressants helped as I still felt run down all the time, but I had enough when they caused me to start putting on weight (a common side effect). I tried to come off cold turkey but that caused a lot of discomfort, so I saw a doctor privately. Together we built a plan to gradually reduce my dose of anti-depressants and gradually add in and increase Neuraleaf CBD. Now I have been taking Neuraleaf CBD for 5 months, I have been off antidepressants for 3 months. My mental health is better than ever – however, I am not cured. I still have some down days, but my quality of life has improved, and my work life and family life has dramatically improved. I’m due for a promotion soon and I think this definitely had something to do with it!