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What is the Endocannabinoid System?

Reading Time: 5 Minutes
Categories: General News
The Endocannabinoid System

Image source: Starkel Nutrition

The endocannabinoid system (ECS) is a complex cell-signalling system identified in the early 1990s by researchers exploring THC, a well-known cannabinoid. Cannabinoids are compounds found in cannabis.

How does the ECS work?

The ECS involves three core components: endocannabinoids, receptors, and enzymes.

Endocannabinoids

Endocannabinoids, also called endogenous cannabinoids, are molecules made by your body. They’re similar to cannabinoids, but they’re produced by your body.

Experts have identified two key endocannabinoids so far:

These help keep internal functions running smoothly. Your body produces them as needed, making it difficult to know what typical levels are for each.

Endocannabinoid receptors

These receptors are found throughout your body. Endocannabinoids bind to them in order to signal that the ECS needs to take action.

There are two main endocannabinoid receptors:

Endocannabinoids can bind to either receptor. The effects that result depend on where the receptor is located and which endocannabinoid it binds to.

For example, endocannabinoids might target CB1 receptors in a spinal nerve to relieve pain. Others might bind to a CB2 receptor in your immune cells to signal that your body’s experiencing inflammation, a common sign of autoimmune disorders.

Enzymes

Enzymes are responsible for breaking down endocannabinoids once they’ve carried out their function.

There are two main enzymes responsible for this:

What are its functions?

The ECS is complicated, and experts haven’t yet determined exactly how it works or all of its potential functions.

 However, the following has been linked to the ECS:

These functions all contribute to homeostasis, which refers to the stability of your internal environment. For example, if an outside force, such as pain from an injury or a fever, throws off your body’s homeostasis, your ECS kicks in to help your body return to its ideal operation.

Today, experts believe that maintaining homeostasis is the primary role of the ECS.

Does the body naturally produce endocannabinoids?

Once scientists discovered cannabinoid receptors in the body, investigations began to determine whether humans produced endocannabinoids.

This led to the discovery of several chemicals similar to THC, such as AEA. AEA activates both CB1 and CB2.

Now, we know around seven of these chemicals exist within the body. As noted, the endocannabinoid system plays an important role in homeostasis and is involved in almost every biological function. In fact, the dysregulation of the ECS underpins some illnesses and pathologies.

How does CBD interact with the human body?

CBD does not interact with the endocannabinoid system in the same manner as THC.

Firstly, it does not activate either the CB1 or CB2 receptors. One of the characteristics that make CBD so unique is that it interacts with different protein receptors and enzymes in the body.

This causes its polypharmacological effects, as demonstrated by the licensed CBD medicine which treats epilepsy. As research develops, CBD is being used to relieve a wide array of symptoms and conditions.

This clinical research will build on the back of extremely strong anecdotal evidence from thousands of patients who have reported improvements in a wide array of afflictions.

As research progresses, dysregulation of the endocannabinoid system (ECS) is found to be implicated in many conditions, often due to low levels of endogenous cannabinoids.

CBD, activating the same receptors as endocannabinoids, replenishes cannabinoid levels and returns homeostatic balance to the ECS, alleviating whatever issue was manifesting as a result of this ECS imbalance. 

Read: CBD Not a Narcotic Drug
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How to Recycle CBD Bottles

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Categories: General News

If you use CBD oil regularly, you may find yourself with a growing collection of empty tincture bottles. how to recycle cbd bottle

The purpose of this article is to discuss how to recycle your empty CBD tincture bottles.

Can CBD Oil Bottles Be Recycled?

Yes, in most cases your glass tincture bottles can be recycled. You can check your local recycling program guidelines to confirm that glass bottles can be placed in your regular recycling bin. If not, your area may still offer curbside pickup or drop-off locations to recycle glass.

You can find out more here: https://www.recyclenow.com/local-recycling

If you’re going to recycle the bottle, it should ideally be clean but it doesn’t have to be spotless. Rinsing the bottle out with warm water should suffice.

You should also remove the dropper top and either dispose of it or reuse it separately. For example, some users keep an extra dropper on hand if they are sharing their CBD with another person, or just in case they lose the dropper.

New to CBD?

We’re happy to help anyone new to CBD to give them the best advice possible. We are the only CBD retailer run and supported by experts.

If you would like advice on which CBD product to use, please don’t hesitate to get in touch with our team of experts.

Are you a professional in a high-stress job?

Read here how CBD can help professionals in high-stress jobs.
https://neuraleaf.co.uk/cbd-for-professionals-in-high-stress-jobs/

CBD for Professionals in High Stress Jobs

Reading Time: 4 Minutes
Categories: General News

You’re a professional, working in a fast paced environment, either from home or in a big office in a big city. You’re ambitious, you’re moving forward in your career, and you want to continue advancing your career and salary.

But with promotion comes greater responsibility, and with greater responsibility comes greater stress. Stress can impact your quality of life and in turn, the quality of your work. Stress can manifest in different ways, impacting your quality of sleep, intellectual capacity, attention, focus, stream of thought and energy levels. These will all lead to a decrease in productivity and efficiency at work and outside of work. Your capacity for social interaction is reduced, leading you to miss valuable networking opportunities. Your emotional intelligence is decreased, leading you to miss out on subconscious cues that can be vital to closing a deal or winning new clients.

It can lead to worse physical health outcomes by increasing the level of general inflammation in the body, increasing risk of autoimmune disease, and weaken the immune system, increasing risk of infections. This can require extended periods of sick leave, which can again harm your career progression.

Stress is also a leading cause of anxiety, depression and can even trigger more significant issues such as bipolar disorder or schizophrenia, especially if there is a family history. The consequences of these disorders cannot be emphasised enough and can lead to the destruction of relationships, inability to work, panic attacks, inability to sleep or inability to wake up, inability to eat, and possibly even psychosis where you may be a danger to yourself or others, and require being sectioned within a secure psychiatric facility.

This may seem like scaremongering, but it is proven by science and by statistics. Record numbers of talented and hard-working professionals are experiencing levels of stress that exceed acceptable levels by some margin, resulting in burnout. The lucky ones will realise this, and take a sabbatical or resign their job in order to repair their mental health, but not everyone has this level of self-awareness. Many will continue to fight through until they are let go from work due to poor results, or suffer a mental breakdown and severe mental health issues thereafter.

We can all agree that while the former is the superior option, neither is ideal. Ideally, you don’t want to take a break from your career at all. Doctors tend to provide really specific advice: Reduce responsibility and workload at work, sleep more, eat better, meditate (mindfulness) and exercise. This is really good advice, but it’s easier said than done. Almost all of those options require a finite resource: time. And as a busy professional, you barely have time to sleep 6 hours, go to work, complete projects at home, eat and exercise if you’re lucky. Most of the time- it’s not possible to do all of them, you must choose. And most of the time, it’s sleep and exercise that suffer, the two most vital. The solution – more time, but there are only 24 hours in the day. Previously, there was no healthy solution.

Drugs work, cocaine and Ritalin to focus and stay awake, Xanax and Valium to wind down and kill anxiety. But the disadvantages far outweigh the potential advantages – that was until now.

A new option for reducing anxiety, improving sleep and quality of life is CBD.

How can CBD help a busy professional?
Professionals working in stressful jobs have reported great results when using CBD for the following:

Why aren’t doctors prescribing or recommending CBD? Because the CBD available on the market is of such a poor quality (inaccurate minimal doses, toxins, heavy metals, Class B drug levels), and as such, no doctor would ever recommend such a dangerous product – until now.

Neuraleaf is the ONLY brand recommended by doctors in the UK, and was founded by a British doctor, who suffered from invasive nerve tumours resulting in significant chronic pain, and subsequent mental health issues. He was prescribed a number of pharmaceutical drugs. In the end, most of the burden of his condition was attributed to the side effects of these drugs. With CBD, he was able to come off the drugs and function as a normal healthy human being.

Who uses CBD? Neuraleaf CBD is the only pharmaceutical-grade CBD on the market, and as such, we are recommended by doctors and used by individuals who 1. Are well informed and care what goes into their body and 2. Choose high-quality products over cheaper alternatives. These tend to be busy professionals, and here is some of the feedback we’ve had.

James, Junior Associate, Goldman Sachs.
The main reason I got CBD was for sleep. I had tried CBD before and it didn’t work, until my psychiatrist recommended Neuraleaf as an alternative to sleeping pills.
I can’t get enough sleep, I’m working till after midnight most nights, and I have to be up for 6am. I average about 3-4 hours of sleep per night, and I can just about function. But after a few days of sleeping like this, I am far less productive.
After taking the CBD capsule before bed, I sleep for 3-4 hours but I wake up feeling like I’ve had 6 hours. This is by no means ideal, as my optimum sleep level is 7-8 hours. But it makes all the difference at work, and allows me to maintain close to 100% productivity until the weekend when I can catch up. I’ve recommended this to a few analysts who were struggling, and those who have used have benefitted.

Prakash, Assistant Manager, Financial Advisory, Deloitte
Every time I am set a deadline, the anxiety I feel leads me to prepare and plan ahead to ensure it gets done on time, in this sense, anxiety is not such a bad thing. But when deadlines are changed, when timelines are brought forwards, when a client needs a piece of working changing fully for the next morning, my anxiety gets so bad that its renders me almost useless. I panic, my brain stops working as my thoughts race, and I am unable to produce quality work. I don’t need CBD all the time, but when something unexpected happens, I take 5ml of Ultra Nano liquid, and within 2 minutes I feel calm and able to adjust my thoughts to tackle the new problem. I find it remarkable just how quickly it gets to work.

Anonymous, Senior Consultant, BCG
I’ve been working in consulting for almost 5 years now, and it’s taken a toll on my mental health. I’ve been on antidepressants for 2 years now and the doses gradually increase as my career has advanced and my stress levels increase. I’m not sure if the antidepressants helped as I still felt run down all the time, but I had enough when they caused me to start putting on weight (a common side effect). I tried to come off cold turkey but that caused a lot of discomfort, so I saw a doctor privately. Together we built a plan to gradually reduce my dose of anti-depressants and gradually add in and increase Neuraleaf CBD. Now I have been taking Neuraleaf CBD for 5 months, I have been off antidepressants for 3 months. My mental health is better than ever – however, I am not cured. I still have some down days, but my quality of life has improved, and my work life and family life has dramatically improved. I’m due for a promotion soon and I think this definitely had something to do with it!

CBD Not a Narcotic Drug

Reading Time: 3 Minutes
Categories: General News

CBD not considered a narcotic drug

CBD is not considered a ‘narcotic drug’ under European law

Cannabidiol extracted from Cannabis plants should no longer be considered a drug, following a judgement from the European Court of Justice (ECJ) in November 2020.

Under the 1961 United Nations Single Convention on Narcotic Drugs, the unauthorised sale of “cannabis flowers” and “extracts and tinctures of cannabis” should fall subject to criminal penalties. However, cannabis flowers and extracts contain several different cannabinoids, with greatly varying concentrations and uses, and so therefore this blanket approach for all cannabis extracts is no longer relevant.

The two most extensively studied cannabinoids are Tetrahydrocannabinol (THC) and Cannabidiol (CBD). THC is known as the main psychoactive component of the cannabis, and is what provides the “high”. Meanwhile, a recent review by the World Health Organizations Expert Committee on Drug Dependence found that CBD ‘has no potential for abuse and no potential to produce dependence’. For that reason, CBD will no longer be considered a narcotic drug under European law.

This ruling stems from a French case, wherein 2017 a court convicted the seller of e-cigarette cartridges containing CBD that had been legally extracted from the whole hemp plant in Czechia, because in France only fibre and seeds are legal hemp. The case was then referred to the ECJ, whereby it was found that, while evidence of the risk to health from CBD was still limited & may justify precautionary restrictive measures, it was inconsistent to apply the marketing ban only to organic, and not synthetic, CBD. The court also stated that CBD extracted from cannabis was not a drug within the meaning of the 1961 Convention; and that the EU industrial hemp regulations were not applicable to the CBD extract, as it is not an agricultural product within those regulations’ definitions.

In recent press briefings following the ruling, the European Commission has also noted that cannabidiol should not be considered a drug, and can indeed be qualified as food, provided the EU Food Safety Regulation conditions are met.

This means that genuine products such as CBD capsules, drops, balms & edibles are now legal across Europe, provided that they contain less than the legal limit of THC.

Read:

How CBD Affects the Brain
Bioavailability of CBD